Understanding of Priligy mechanism of action
The mode of action of Dapoxetine (the main component in Priligy) is not obvious enough. The scientists consider that the medicine works by blocking serotonin transporter and hereinafter improving serotonin action at its receptors. The ejaculation is proven to be controlled by different areas in the CNS (central nervous system).
The signals are send from the brain to spinal cord and then to the genital area. Dapoxetine stops the ejaculatory expulsion reflex and inflects the control over the desire to ejaculate in men. It was noticed that all SSRIs caused a certain delay in time to ejaculation. This side effect was used as a modern approach in the treatment of men who had early ejaculations. Still not all SSRIs antidepressants can be used for this medical purpose. Only short-acting medicine Dapoxetine is proven to be the safest treatment for PE. This medicine acts quickly and is quickly eliminated from the body, causing no ill-effects.
Is it possible to use Priligy with oral ED drugs?
Some men want to know if they can use Dapoxetine for their PE problem together with oral anti-impotence agents such as Viagra, Cialis or Levitra used to treat erectile dysfunction. Yes, the use of oral ED meds and Priligy is possible in men who experience both PE and ED. There is no evidence that Dapoxetine interacts with oral PDE-5 inhibitors such as Sildenafil (Viagra), Tadalafil (Cialis) or Vardenafil (Levitra). In special study conducted in 2006 to estimate the possibility of Dapoxetine interactions with oral PDE-5 inhibitors. The data obtained from the study confirmed that Dapoxetine 60 mg with Tadalafil 20 mg (the max dose) and Dapoxetine 60 mg with Sildenafil 100 mg (the max dose) were absolutely safe.
The results showed that Dapoxetine did not change the pharmacokinetic of Tadalafil and Sildenafil. Thus men can combine one of these medicines with Priligy. The medicines should be used in therapeutic doses to avoid side effects. As the clinical trials show Dapoxetine does not produce any serious drug interactions. Still before using Priligy it is better to discuss with your doctor if it is safe for you to combine drugs which you use with Dapoxetine.