Priligy important information
Understanding of Priligy mechanism of action
The mode of action of Dapoxetine (the main component in Priligy) is not obvious enough. The scientists consider that the medicine works by blocking serotonin transporter and hereinafter improving serotonin action at its receptors.
The ejaculation is proven to be controlled by different areas in the CNS (central nervous system). The signals are send from the brain to spinal cord and then to the genital area.
Dapoxetine stops the ejaculatory expulsion reflex and inflects the control over the desire to ejaculate in men. It was noticed that all SSRIs caused a certain delay in time to ejaculation.
This side effect was used as a modern approach in the treatment of men who had early ejaculations. Still not all SSRIs antidepressants can be used for this medical purpose. Only short-acting medicine Dapoxetine is proven to be the safest treatment for PE. This medicine acts quickly and is quickly eliminated from the body, causing no ill-effects.
Is it possible to use Priligy with oral ED drugs?
Some men want to know if they can use Dapoxetine for their PE problem together with oral anti-impotence agents such as Viagra, Cialis or Levitra used to treat erectile dysfunction.
Yes, the use of oral ED meds and Priligy is possible in men who experience both PE and ED. There is no evidence that Dapoxetine interacts with oral PDE-5 inhibitors such as Sildenafil (Viagra), Tadalafil (Cialis) or Vardenafil (Levitra).
In special study conducted in 2006 to estimate the possibility of Dapoxetine interactions with oral PDE-5 inhibitors. The data obtained from the study confirmed that Dapoxetine 60 mg with Tadalafil 20 mg (the max dose) and Dapoxetine 60 mg with Sildenafil 100 mg (the max dose) were absolutely safe. The results showed that Dapoxetine did not change the pharmacokinetic of Tadalafil and Sildenafil.
Thus men can combine one of these medicines with Priligy. The medicines should be used in therapeutic doses to avoid side effects.
As the clinical trials show Dapoxetine does not produce any serious drug interactions. Still before using Priligy it is better to discuss with your doctor if it is safe for you to combine drugs which you use with Dapoxetine.
Priligy side effects
Men who use Priligy do not usually notice any changes in health or their condition when they start taking this medicine. Some of men may experience nausea, dizziness, dry mouth, headaches, insomnia and diarrhea. Still men do not stop using the medicine due to these side effects of the drug. One Asian study shows that the percent of stop in use due to side effects is 1.7 % of patients using 30 mg of dapoxetine. According to this study the stop in dapoxetine use is dose-related.
Dapoxetine is an antidepressant, but unlike other medicines from this drug class dapoxetine does not cause any side effects associated with antidepressants. It does not cause any changes in sexual drive or erectile function.
As the medicine is short-acting in the body, it is considered to be very safe if used in the therapeutic doses.
PE is often considered to be an illness affecting mostly younger males who do not have sexual experience and proper control over their body. The fact is – many men who experienced PE problem in their 20-30s have overcome it with age. This happens mostly due to better grip over the situation. Others cannot get rid of the problem even with age. For such men a medical help is really needed.
One of the modern medicines applied to treat premature ejaculation problem is Priligy. It assures better control over ejaculation and is used to delay an orgasm in men who really have the problem.
Generic Priligy medicine can be easily ordered online. This medicine is a generic analogue and contains Dapoxetine as a main component. The medicine is affordable for all men who need regular treatment.
The cause (s) of premature ejaculation is not really known. Still experts consider mental and emotional disturbances to be the reasons behind early ejaculation.
Depressive disorders, nervousness and stress hinder the normal process of erection for the time necessary for sexual intercourse.
Anxiety, fears and certain changes in the brain chemicals can be also the factors influencing on a man’s ability to control his ejaculation.
Generic Priligy is developed to deal with ejaculations that happen earlier than needed. This medicine regulates the time to ejaculation and prolongs the sexual intercourse to the normal time.
Why does ED come to you?
In younger people the most frequent cause of ED is uncertainty and anxiety; in particular the man may be nervous about having sex, about possible pregnancy of his girl or about how to use the condom.
Many young men confide that they can’t use the condom properly because when they are trying to put it on, they feel losing their erection. In this case the doctors talk about ‘condom collapse syndrome’.
A most common reason of this group is overwork, work pressure and often stress situation, sense of guilt or bereavement: erectile dysfunction often occurs when a widowed man tries to begin a new sexual relationship. And only few cases are caused by health problems such as diabetes or obesity, as well the poor habits such as excessive drinking or much smoking, drugs using.
Priligy limitations of use
Priligy has certain limitations of use. The medicine should not be used in some categories of patients including those with hypersensitivity or allergic reactions to Dapoxetine.
Priligy is not applied in men with serious health conditions such as heart disease, liver or kidney function impairment.
The cases when Dapoxetine should be used with caution are patients with diabetes, men using other medicines.
Certain medications are contraindicated with Dapoxetine: CYP3A4 inhibitors (ketoconazole, ritonavir, telithromycine); other antidepressants including SSRIs, serotonin-norepinephrine reuptake inhibitors, monoamine oxidase inhibitors.
For men who fall into the mentioned above categories it is better to consult their doctors before Priligy use.
Priligy (Dapoxetine) approval history and status
Dapoxetine under the name of Priligy is known to numerous number of men suffering from premature ejaculation. Doctors recommend this medicine as a first-line therapy for this frequent sexual trouble in men. Dapoxetine is considered to be very effective and safe for patients. Still the medicine is not approved by the FDA.
Priligy is used in men from 18 years of age. The use of the medicine in older men is not recommended due to their increased ability to improve the condition naturally. With age men learn better how to control their ejaculation.
During first clinical studies of this medicine it was noticed that one of its side effects included delay in ejaculation. Dapoxetine was decided to be applied for approval as a medicine for PE treatment in men. The antidepressant effects of this medicine are relatively weak in comparison with other SSRIs due to its short action in the body. Unlike other SSRIs, Priligy is absorbed and eliminated rapidly. Its fast acting characteristic suits the requirement of PE treatment and is not effective for depressive disorders.
The origin of the medicine belongs to pharmaceutical giant Eli Lilly. In 2003 the medicine passed to Johnson &Johnson Company.
The medicine is approved in several European countries, Asian countries and Mexico.
The rights for selling this medicine were obtained by Menarini in 2012. So far this medicine has not received the approval status from the FDA.
Priligy medicine is a common treatment for men with premature ejaculation disturbance. This remedy is an antidepressant which helps to overcome early climaxing and provides reduction of stress and nervousness often accompanying PE.
For most patients, the starting dose is 60 mg of Priligy. Some males are advised to use 30 mg or 60 mg of Priligy.
In clinical trials of Priligy the group of males taking 60 mg of Dapoxetine had the optimal results in treatment and practically no side effects.
The dose of Dapoxetine can be increased to 100 mg and 120 mg. With the dose increase, the risk for side effects development also increases. If your dose helps you, do not exceed it. If you think that your dose is not working properly, consult your doctor first.
There are some men who do not respond to lower doses. They require Priligy 100 mg and Priligy 120 mg.
Priligy is used 1 to 3 hour before sexual activity. The medicine is most powerful within 1-2 hours post dose and can last for 4 to 6 hour.
Priligy (Dapoxetine) general information
Priligy medicine is an oral therapy for male patients who experience problems with early or premature ejaculation. The medicine is indicated to keep erections and postpone ejaculation. Priligy’s main component Dapoxetine hydrochloride provides men with better control over climaxing and improves the average time to ejaculation in such men.
The therapeutic category of Dapoxetine is selective serotonin reuptake inhibitor (SSRI). It belongs to antidepressant agents, but is characterized by short action time.
Dapoxetine clinical trials have observed the efficiency of this substance in thousands of males suffering from premature ejaculation. The action of the medicine involves the increase in the amounts of serotonin in the brain and thereby enhancement of the control over ejaculation.
Dapoxetine should be used with a doctor’s approval.
The regular use of the medicine will help to get more control over the problem.
Priligy is used when necessary just before sexual activity.
The medicine is to be taken orally with a full glass of water.
It is necessary to take the prescribed dose not more than once a day.
The medicine is available in the form of tablets for oral use in the doses of 30 mg, 60 mg and 100 mg. The dose choice depends on the general health, other medicines used, respond of a patient and severity of the condition.
This medicine should be stored at room temperature away from heat, light, and moisture.
Priligy – an ideal PE medicine
Priligy medicine represents the best existing oral therapy for premature ejaculation problem. This medicine contains Dapoxetine which helps avoiding early climaxing and ejaculation in men.
Premature ejaculation or PE is a common sexual disturbance characterized by a man’s inability to sustain and control climax for the normal time of sexual intercourse. The problem appears in men who cannot delay ejaculation until penetration or lose control soon after penetration. The time to ejaculation in such men is less than 2 minutes. The problem causes frustration, stress and fears to perform badly.
Priligy medicine is indicated to help men in postponing and maintaining climax until the necessary time. It allows a man and his partner to have sexual intercourse full of pleasures. This medical product can be ordered online without prescription. Still a doctor’s advice is always encouraging.